| 胃癌发生过程中细胞膜磷脂变化的研究 |
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| 引用本文： | 张佳,叶尔买克,王健生,吴文安,王嗣岑,张明鑫,周苏娜.胃癌发生过程中细胞膜磷脂变化的研究[J].陕西肿瘤医学,2010,18(5):855-857. |
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| 作者姓名： | 张佳 叶尔买克 王健生 吴文安 王嗣岑 张明鑫 周苏娜 |
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| 作者单位： | [1]西安交通大学医学院第一附属医院肿瘤外科,陕西西安710061 [2]西安交通大学医学院药物研究所,陕西西安710061 |
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| 基金项目： | 国家自然科学基金资助项目（编号：30600744） |
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| 摘 要： | 目的：检测胃癌原发灶及癌旁黏膜组织细胞膜磷脂含量，探讨其与胃癌发生的关系。方法：采用高效液相色谱法检测胃癌原发灶及癌旁黏膜组织细胞膜PI、Ps、PE和Pc的含量。结果．30例胃癌患者中原发灶和癌旁黏膜组织中细胞不同膜磷脂的含量（mg／g）：PI为1．69±0．09和1．18±0．10；PS为0．55±0．04和0．54±0．04；PE为52．57±5．58和27．54±3．36；PC为121．364-6．49和62．90±5．02。癌与癌旁黏膜组织中Ps的含量差异无显著性意义（P〉0．05）。结论：胃癌发生过程中胃癌原发灶中PI、PE、PC含量高于癌旁黏膜组织（P〈0．01）。胃癌原发灶与癌细胞膜磷脂发生了明显变化，PI、PE、PC增高与胃癌发生有关。
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| 关 键 词： | 胃癌 细胞膜 膜磷脂 |
Variations of cellular membrane phospholipids with genesis of gastric cancer |
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| Institution: | ZHANG Jia ,YE Er - mai - ke, WANG Jian - sheng, WU Wen - an, WANG Si - cen, ZHANG Ming - xin, ZHOU Su - na( 1First Affiliated Hospital of Xi＇an Jiaotong University ,Xi＇an 710061, China ;2School of Medicine ,Xi＇an Jiaotong University ,Xi＇an 710061, China.) |
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| Abstract: | Objective： To detect membrane phospholipids and study the relationship of membrane phospholipids with genesis of gastric cancer. Methods： Membrane phospholipids of PI, PS, PE, and PC were detect with high per- formance liquid chromatography. Results： In primary loci and paratumor gastric mucosa of 30 cases, the content of PI were （rag/g） ： 1.69 ± 0.09,1.18 ±0. 10 respectively, PS 0.55 ± 0.04,0.54 ± 0.04 respectively, PE 52.57 ± 5.58, 27.54 ± 3.36 respectively, and PC 121.36 ± 6. 49 , 62. 90 ± 5.02 respectively. The contents of PI , PE and PC were higher in primary foci than in paratumor mucosa（ P 〈 0.01 ）. PS in primary loci and paratumor gastric mucosa was not significantly different（ P 〉 0.05 ）. Conclusion： Membrane phospholipids have obvious variations in genesis of gastric cancer. Rises of PI, PE and PC were associated with genesis of gastric cancer. |
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| Keywords: | gastric cancer cell membrane phospholipids |
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