| 维生素B2注射液中镉、砷和铅的电感耦合等离子体质谱法测定 |
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| 引用本文： | 甘盛,施晓光,韩婷,吴超权. 维生素B2注射液中镉、砷和铅的电感耦合等离子体质谱法测定[J]. 中国医药工业杂志, 2012, 43(4): 298-300 |
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| 作者姓名： | 甘盛 施晓光 韩婷 吴超权 |
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| 作者单位： | 1. 广西壮族自治区食品药品检验所,广西南宁,530021
2. 河北联合大学基础药学院药理教研室,河北唐山,063009 |
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| 摘 要： | 建立了电感耦合等离子体质谱法测定维生素B2注射液中的镉、砷和铅.维生素B2注射液经过微波消解,使用铟、锗、铋作为内标元素进行校正,以杨树叶为质控标准物,镉和铅在1～100 ng/ml、砷在1～150 ng/ml浓度范围内线性关系良好,回收率为92.4％～101.7％,RSD小于4.1％.
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| 关 键 词： | 维生素B2注射液 电感耦合等离子体质谱法 重金属 测定 |
Determination of Cadmium,Arsenic and Lead in Vitamin B2 Injection by Inductively Coupled Plasma-Mass Spectrometry |
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| GAN Sheng , SHI Xiaoguang , HAN Ting , WU Chaoquan. Determination of Cadmium,Arsenic and Lead in Vitamin B2 Injection by Inductively Coupled Plasma-Mass Spectrometry[J]. , 2012, 43(4): 298-300 |
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| Authors: | GAN Sheng SHI Xiaoguang HAN Ting WU Chaoquan |
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| Affiliation: | 1(1.Guangxi Institute for Food and Drug Control,Nanning 530021; 2.Didactic and Research Section of Pharmacology,College of Fundamental Pharmacy,Hebei United University,Tangshan 063009) |
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| Abstract: | An inductively coupled plasma mass spectrometry method was established for the determination of cadmium,arsenic and lead in vitamin B2 injection.The vitamin B2 injection samples were digested by microwave,with indium,germanium and bismuth as the internal standard elements and poplar leaves as the controlled reference standard.Both cadmium and lead were linear in the range of 1-100 ng/ml,while arsenic was linear in the range of 1-150 ng/ml.The recoveries were 92.4%-101.7%,with RSDs less than 4.1%. |
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| Keywords: | vitamin B2 injection inductively coupled with plasma mass spectrometry heavy metal determination |
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