泮托拉唑治疗十二指肠溃疡的系统评价

目的:评价泮托拉唑治疗十二指肠溃疡的临床疗效和安全性。方法:检索泮托拉唑与其他H2受体拮抗剂治疗十二指肠溃疡的临床随机对照研究,筛选符合纳入标准临床研究,应用Juni评分法进行评价,运用RevMan 5.0软件对相关数据进行Meta分析。结果:根据标准筛选出21篇文献,Meta分析结果显示:泮托拉唑与雷尼替丁治疗十二指肠溃疡的2周溃疡愈合率:OR=3.11,95%CI=(2.46,3.94),(P<0.05);4周溃疡愈合率:OR=5.72,95%CI=(4.16,7.85),(P<0.05);泮托拉唑与法莫替丁治疗十二指肠溃疡的4周溃疡愈合率:OR=4.70,95%CI=(1.96,11.28),(P<0.05);泮托拉唑与西咪替丁治疗十二指肠溃疡的4周溃疡愈合率:OR=3.80,95%CI=(1.89,7.65),(P<0.05)。在不良反应发生率方面差异无显著性。结论:与雷尼替丁﹑法莫替丁﹑西咪替丁相比较,泮托拉唑具有起效迅速、临床症状缓解快、溃疡愈合率高等优点,是治疗十二指肠溃疡的优选方案。

System evaluation of the efficacy of pantoprazole in treating duodenal ulcer patients

OBJECTIVE To evaluate the efficacy and safety of pantoprazole in treating duodenal ulcer patients.METHODS Searching published article,both at home and abroad,about pantoprazol in treating duodenal ulcer through literature and Internet queries.The forest plot with Meta analysis was drawn by RevMan 5.0.RESULTS According to the criterion 21 literatures were selected.Meta analysis showed: 2 weeks healing rate of pantoprazole and ranitidine in treating duodenal ulcer OR=3.11,95% CI =(2.46,3.94),(P<0.05);4 weeks healing rate OR=5.72,95% CI =(4.16,7.85),(P<0.05);4 weeks healing rate of pantoprazole and famotidine in treating duodenal ulcer:OR=4.70,95% CI=(1.96,11.28),(P<0.05);4 weeks healing rate of pantoprazole and cimetidine in treating duodenal ulcer:OR=3.80,95% CI=(1.89,7.65),(P<0.05).There were no significant differences in the incidence of adverse reactions.CONCLUSION Compared with ranitidine,famotidine and cimetidine,pantoprazole has advantages of instant effect,easing symptoms quickly,and high rate of ulcer healing over famotidine.So pantoprazole is the better choice for the treatment of duodenal ulcer patients.