高血压病患者血压变异性与认知功能的相关性研究

目的探讨高血压病患者血压变异性与认知功能的关系。方法收集到该院就诊的180例高血压病患者进行动态血压检测,并收集一般临床资料,测量身高、体重,测定空腹血糖,总胆固醇,甘油三酯等指标。同时根据国际通用的简易智力状况量表(MMSE)得分进行认知功能评定,将患者分为2组:认知功能障碍组作为病例组41例,认知功能正常组作为对照组139例。结果单因素分析结果显示:年龄、文化程度、饮酒史、24h收缩压变异及收缩压晨峰5个因素在病例组和对照组之间的差异有统计学意义(P<0.05);Logistic多因素回归分析显示,高血压病患者年龄,文化程度,24h收缩压变异及收缩压晨峰与其认知功能下降有关(OR值分别是1.11、10.42、2.42和4.39,P均<0.05)。结论该研究的高血压病人群除文化程度和年龄因素外,24h收缩压变异及收缩压晨峰与认知功能降低密切相关,高血压病患者收缩压的变异异常和收缩压晨峰是其认知功能障碍重要的危险因素。

Relationship between blood pressure variability and cognition in hypertensive patients

【Objective】 To study the relationship between blood pressure variability and cognition in hypertensive patients.【Methods】 180 hypertensive patients were included.24h dynamic blood pressure was determined.Height and body weight were measured.Then blood samples were taken from them for measurement of biochemical indicators.Finally,we applied the Mini Mental State Examination(MMSE) to test the cognitive function and calculate scores.The hypertensive patients were divided into two groups: the patients with impaired cognition ware classified as case group(n =41),the patients with normal cognition as control group(n =139).【Results】 Univariate analysis showed that significant difference were found in age,educational level,drinking,24 h SBP variability and morning SBP surge between case group and control group.Multivariate logistic regression analysis showed that age(OR=1.11,P <0.05)、educational level(OR=10.42,P <0.05),24 h SBP variability(OR=2.42,P <0.05) and morning SBP surge(OR=4.39,P <0.05) were correlated to cognitive impairment.【Conclusions】 In this study,besides educational level and age,24 h SBP variability and morning SBP surge are correlated with cognitive impairment.It implies that SBP variability and morning SBP surge are the important risk factors for the cognitive impairment in hypertensive patients.