地佐辛和舒芬太尼超前镇痛用于腹腔镜手术患者的疗效观察

目的:考察雷米芬太尼复合丙泊酚静脉全麻的腹腔镜患者应用地佐辛和舒芬太尼超前镇痛的有效性和安全性。方法:选择40例行腹腔镜手术的患者,随机分为2组,各20例,Ⅰ组麻醉诱导前5 min静注地佐辛0.1 mg·kg-1,Ⅱ组麻醉诱导前5 min静注舒芬太尼0.1μg·kg-1,记录拔管时间,术后2 h疼痛视觉模拟评分(VAS)、Ramesay评分、舒适度评分(BCS)、首次使用镇痛药时间及术后相关并发症。结果:Ⅰ组比Ⅱ组的拔管时间早,术后2 h VAS、BCS和术后并发症的发生率2组间差异均无统计学意义,术后2 h Ramesay评分Ⅰ组比Ⅱ组低,Ⅰ组首次使用镇痛药时间较早。结论:地佐辛和舒芬太尼具有同样的镇痛效果,但地佐辛镇痛持续时间较短,舒芬太尼比地佐辛可能会引起拔管时间晚和更深的镇静。

Effects of preemptive analgesia with dezocine and sufentanil in laparoscopic patients

OBJECTIVE To observe the efficacy and safety of preemptive analgesia with dezocine and sufentanil in the laparoscopic patients with remifentanil and propofol intravenous anesthesia.METHODS Forty laparoscopic patients were randomly and averagely assigned to receive intravenous injection of 0.1 mg·kg-1 dezocine(groupⅠ) and 0.1 μg·kg-1sufentanil(groupⅡ) 5 minutes before anesthesia.The extubation time,the time of first use of analgesic after operation,the incidence of interrelated complication and visual analogue score(VAS),Ramesay score,Bruggman comfort scale(BCS) in two hours after surgery were recorded.RESULTS Compared with group Ⅱ,the extubation time and the time of first use of analgesic after operation were earlier in groupⅠ(P<0.05).There were no significant differences in the incidence of interrelated complication,VAS and BCS in two hours after surgery between two groups.Ramesay score was lower in groupⅠ than group Ⅱ(P<0.05).CONCLUSION Dezocine and sufentanil have the same analgesic effect.But dezocine has shorter duration of analgesia than sufentanil,and sufentanil may lead to later extubation and deeper sedation than dezocine.