巴洛沙星的体外抗菌作用研究

目的评价巴洛沙星的体外抗菌作用。方法以琼脂稀释法测定巴洛沙星对临床分离菌的最低抑菌浓度，并与有关抗菌药进行比较；测定巴洛沙星的杀菌作用，观察巴洛沙星的抗菌活性影。结果巴洛沙星对革兰氏阳性菌及革兰氏阴性菌具广谱抗菌活性，尤其对葡萄球菌、肺炎球菌、肠球菌等革兰氏阳性菌活性优于诺氟沙星、氧氟沙星和环丙沙星。巴洛沙星有较强的杀菌作用，其MBC与MIC相一致，在体外具有较长的抗菌后效应。结论巴洛沙星是一种广谱抗菌药，抗菌作用强，临床应用前景好。

In vitro antibacterial activity of Balofloxacin

Objective To evaluate the activity of Balofloxacin in vitro.Methods The minimal inhibitory concentration(MIC) of Balofloxacin against clinical isolates were determined and compared with other antimicrobial agents using agar dilution method.The bactericidal activity of Balofloxacin was investigated.Results The results showed that Balofloxacin had broad-spectrum activity.It was highly active against Staphylococcus,Streptococcus pneumonia,Enterococcus.Balofloxacin was obviously more active against Staphylococcus,Streptococcus pneumonia and Enterococcus than Norfloxacin,Ofloxacin and Ciprofloxacin.Balofloxacin is a bactericidal agent and the minimum bactericidal concentration(MBC) was equal to MIC.In vitro Balofloxacin had long postantibiotic effect.Conclusions Balofloxacin is a broad-spectrum agent;it is highly active against most bacteria.