|
|||||
|
|
Endogenous opioid systems: Physiological role in the self-limitation of seizures |
|
| Authors: | Frank C. Tortella Joseph B. Long John W. Holaday |
| Affiliation: | 2. Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA;3. Portland Alcohol Research Center, Portland VA Medical Center, Portland, Oregon, USA;1. Faculté de Médecine, Université Laval, Québec, QC;2. Service de Gynécologie-Obstétrique et Médecine de la Reproduction, CHU de Nantes, Nantes, France;3. CHU de Québec-Université Laval Research Center, Québec, QC;4. Department of Obstetrics and Gynecology, CHU de Québec-Université Laval, CHU de Québec-Université Laval Research Center, Québec, QC |
| Abstract: | Immediately following a seizure, the severity of subsequent seizures is significantly reduced. The involvement of endogenous opioid systems as a physiological regulator of this postseizure inhibition was studied in rats using repeated maximal electroshock (MES) seizures. Both the opiate antagonist (−)-naloxone and morphine tolerance abolished the progressive seizure protection associated with repeated MES. We propose that endogenous opioids, activated by a prior seizure, provide a central homeostatic inhibitory mechanism which may be responsible for the initiation of a postictal refractory state in the epileptic. |
| Keywords: | maximal electroshock (MES) seizures endogenous opioids postseizure inhibition naloxone morphine tolerance |
| 本文献已被 ScienceDirect 等数据库收录！ | |