| 1-[(4-氯苯基)苯甲基]-哌嗪合成方法的改进 |
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| 引用本文： | 金永生,姚斌,吴秋业,赵靖霞. 1-[(4-氯苯基)苯甲基]-哌嗪合成方法的改进[J]. 实用医药杂志(山东), 2005, 22(12): 1108-1109 |
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| 作者姓名： | 金永生 姚斌 吴秋业 赵靖霞 |
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| 作者单位： | 第二军医大学药学院,上海200433 |
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| 摘 要： | 目的探讨西替利嗪的中间体1-犤(4-氯苯基)苯甲基犦-哌嗪的合成方法的改进。方法以氯苯和苯甲酰氯为原料经还原等三步反应得到目标和化合物。结果及结论建立了一种新的合成方法。该法经济实用,收率高达53%,适合工业化生产。
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| 关 键 词： | 西替利嗪 哌嗪 合成 |
| 修稿时间： | 2005-09-19 |
Synthesis of 1-[(4-chlorophenyl)phenylmethyl]-piperazine:A improved method |
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| JIN Yongsehng,YAO Bin,WU Qiuye,et al.. Synthesis of 1-[(4-chlorophenyl)phenylmethyl]-piperazine:A improved method[J]. Practical Journal of Medicine & Pharmacy, 2005, 22(12): 1108-1109 |
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| Authors: | JIN Yongsehng YAO Bin WU Qiuye et al. |
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| Affiliation: | JIN Yongsehng,YAO Bin,WU Qiuye,et al.School of Pharmacy,Second Military Medical University,Shanghai 200433,China |
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| Abstract: | Objective To study improved synthetic method of 1-[(4-chlorophenyl)phenylmethyl]-piperazine, the intermediate of cetirizine hydrochloride.Methods Chlorobenzene and benzoyl chloride were used as starting reagents,and the title compounds were synthesized then by reduction etc.3 steps reaction.Results and Conclusion A novel synthetic method was completed.This method is economical and practical, higher yield(th recovery rate,53%), and were able to be used in industrializations. |
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| Keywords: | Cetirizine Piperazine Synthesis |
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