Abstract: | Acute experiments on rats showed that bradykinin, injected by microiontophoresis, activates sensomotor cortical neurons in rats. Morphine, administered in the same way, prevents the development of the bradykinin effect. Bradykinin, it is suggested, acts on opiate receptors in cerebral cortical neurons.Laboratory of Pharmacology of the Nervous System, Institute of Pharmacology, Academy of Medical Sciences of the USSR. Laboratory of Emotions and Emotional Stresses, P. K. Anokhin Institute of Normal Physiology, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR V. V. Zakusov). Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 86, No. 10, pp. 450–452, October, 1978. |