A light and electron microscopic study of GAT-1-positive cells in the cerebral cortex of man and monkey |
| |
| Authors: | Ong W Y Yeo T T Balcar V J Garey L J |
| |
| Affiliation: | (1) Department of Anatomy, National University of Singapore, Singapore, 119260;(2) Department of Neurosurgery, Tan Tock Seng Hospital, Singapore, 308433;(3) Department of Anatomy and Histology and Sydney Institute for Biomedical Research, University of Sydney, NSW, 2006, Australia;(4) Division of Neuroscience, Imperial College School of Medicine, Charing Cross Hospital, London, W6 8RF, UK |
| |
| Abstract: | SummarySpecimens of human cerebral cortex were obtained during neurosurgical operations and studied by immunocytochemistry and electron microscopy, using antibodies to the GABA transporter GAT-1. Cortical material from macaque monkeys was prepared similarly. Large numbers of GAT-1-positive non-pyramidal neurons were observed in layers I, II, V, and VI of the cortex. Electron microscopy also showed that the GAT-1-positive axon terminals formed symmetrical and not asymmetrical synapses, suggesting that they were the terminals of non-pyramidal neurons. Processes of cells in the walls of blood vessels were also labelled. We conclude that GAT-1 is present in cell bodies and axon terminals of non-pyramidal neurons, and a population of mural cells in blood vessels, in the primate cerebral cortex. |
| |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
