| Inhibitory effects of nimodipine on platelet aggregation and thrombosis |
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| 引用本文： | 任亚军,吕爱刚,张贵卿,贾丹辉. Inhibitory effects of nimodipine on platelet aggregation and thrombosis[J]. Acta pharmacologica Sinica, 1998, 0(2) |
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| 作者姓名： | 任亚军 吕爱刚 张贵卿 贾丹辉 |
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| 作者单位： | 河南医科大学药理教研室 |
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| 摘 要： | 目的：研究尼莫地平（Ｎｉｍ）对大鼠体内血小板聚集和动脉血栓形成的影响．方法：比浊法测定血小板的聚集率和抑制率；电刺激法测定Ｎｉｍ对体内动脉血栓形成的影响，放免法测定Ｎｉｍ对血浆６酮前列腺素Ｆ１α和血栓素Ｂ２（６ｋｅｔｏＰＧＦ１α／ＴＸＢ２）含量的影响．结果：Ｎｉｍ４５，９，１８和３６ｍｇ·ｋｇ－１·ｄ－１ｉｇ４ｄ可显著抑制血小板的聚集．ＩＣ５０（９５％可信限）为２６（９－４４）ｍｇ·ｋｇ－１．Ｎｉｍ４５，９，１８ｍｇ·ｋｇ－１·ｄ－１ｉｇ４ｄ可显著延长电刺激诱导的颈动脉血栓形成时间．Ｎｉｍ９和１８ｍｇ·ｋｇ－１可明显改善血浆中６ｋｅｔｏＰＧＦ１α／ＴＸＢ２的比值．结论：Ｎｉｍ抗血栓作用部分与改善６ｋｅｔｏＰＧＦ１α／ＴＸＢ２比值有关．
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| 关 键 词： | 尼莫地平；血小板聚集；血栓形成；血栓素B_2；6-酮前列腺素F_(1α)；腺苷二磷酸；颈动脉 |
Inhibitory effects of nimodipine on platelet aggregation and thrombosis |
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| REN Ya Jun,L Ai Gang ,ZHANG Gui Qing,JIA Dan Hui. Inhibitory effects of nimodipine on platelet aggregation and thrombosis[J]. Acta pharmacologica Sinica, 1998, 0(2) |
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| Authors: | REN Ya Jun L Ai Gang ZHANG Gui Qing JIA Dan Hui |
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| Affiliation: | REN Ya Jun,L Ai Gang 1,ZHANG Gui Qing,JIA Dan Hui |
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| Abstract: | |
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| Keywords: | nimodipine platelet aggregation thrombosis thromboxane B 2 6 ketoprostaglandin F 1 alpha adenosine diphosphate carotid arteries |
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