透皮促透剂对复方酮康唑乳膏体外透皮吸收的影响

目的：观察不同促透剂对复方酮康唑乳膏中酮康唑在体外透皮作用的影响。方法：采用改良的简单小室装置，以离体鼠皮为透皮屏障，用高效液相色谱法(HPLC)测定含量，计算累积透皮吸收百分率。结果：5种促透使用方法对乳膏中酮康唑均有促透作用。结论：5种促透使用方法最好的为3%双戊烯(DP)＋1.5%氮酮(azone)，然后依次是3%DP、3%薄荷醇(M)、1.5%DP＋1.5%M、2%azone。

Effect of Penetration Enhancers on the Percutaneous Permeability of Compound Ketoconazole Cream in Vitro

Objective:To study the effect of different penetration enhancers on the percutaneous permeability of compound ketoconazole cream in vitro. Methods:Isolated rat skin was taken as the permeable barrier by using a modified simple cell device. The content of ketoconazole was dertermined with HPLC. The accumulative total percentage of percutaneous permeability was calculated. Results:All of the five penetration enhancers were shown to increase the penetration of ketoconazole in the cream. Conclusion:3% dipentane(DP)+1.5% azone was found to have the best penetration enhancing effect, followed successively by 3% DP, 3% menthol(M), 1.5% DP+1.5% M and 2% azone.