尿毒症患者在肾移植围手术期血浆神经肽Y含量变化及其意义

目的 探讨血浆神经肽Y(NPY)在成功肾移植围术期的变化及其与肾功能的关系.方法 采集45例行同种异体肾移植术的尿毒症患者术前、术后24 h、出院前1 d外周静脉血标本5 ml,测定血浆NPY、血清尿素氮(BUN)、肌酐(Cr)水平.对照组为20例健康志愿者.结果手术前的血浆NPY平均值(400.8±105.6)ng/L较对照组20例健康志愿者的血浆NPY水平(77.2±16.6)ng/L显著升高(P<0.01).术后24 h血浆NPY较术前略有降低(P>0.05).出院前1 d血浆NPY较术前显著降低(P<0.05),但明显高于健康志愿者血浆NPY水平(P<0.05).结论 肾移植术后尿毒症患者的血浆NPY水平在肾功恢复正常后明显下降,血浆NPY浓度在一定程度上可以作为肾移植围术期肾功能的评估指标之一.

The perioperative changes and clinical significance of the plasma neuropeptide Y concentration in renal transplantation patients

Objective To explore the perioperative changes of the plasma neuropeptide Y (NPY)level and its relationship with the renal function in renal transplantation patients.Methods Plasma concentrations of NPY,ereatinine and urea nitrogen in 45 patients with chronic renal failure (CRF) before and 24 h after renal transplantation,and one day before discharge from hospital.Twenty healthy volunteers served as controls.Results Plasma NPY concentration was higher significantly in CRF patients than in healthy controls ( P ＜ 0.01 ).NPY level of patients was decreased significantly one day before discharge from hospital as compared with that before transplantation ( P ＜ 0.05 ).There was a significant correlation between plasma NPY concentration and renal function in renal transplantation patients (P ＜ 0.05 ).Condusion Plasma NPY concentration was significantly decreased when renal function was normal after renal transplantation,implying that NPY level detection can be considered as an alternative to assess renal function.