| 牛膝多糖研究进展 |
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| 引用本文： | 时春娟,周永达,张剑波,田庚元.牛膝多糖研究进展[J].中国新药杂志,2006,15(16):1330-1334. |
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| 作者姓名： | 时春娟 周永达 张剑波 田庚元 |
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| 作者单位： | 1. 华东师范大学化学系,上海,200062
2. 中国科学院上海有机化学研究所生命有机化学国家重点实验室,上海,200032 |
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| 基金项目： | 教育部留学回国人员科研启动基金;中国科学院上海有机化学研究所科研基金;华东师范大学校科研和教改项目;上海市自然科学基金 |
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| 摘 要： | 牛膝多糖是从中药牛膝的干燥根里分离得到的果聚糖，相对分子质量小，水溶性好，易被人体吸收，具有广谱的免疫调节活性。牛膝多糖经结构修饰（硫酸酯化，磷酸酯化，羧甲基化，羟甲基化）后得到的一系列的多糖衍生物显示出更高的活性或新的生理活性，具有广阔的药物开发及应用前景。现对牛膝多糖的结构、分离、药理活性、及其衍生化修饰等方面的最新研究进展进行综述。
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| 关 键 词： | 牛膝多糖 果聚糖 理化性质 药理活性 衍生物 |
| 文章编号： | 1003-3734（2006）16-1330-05 |
| 修稿时间： | 2006-03-10 |
Researches of polysaccharides from Achyrnthes bidentata |
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| SHI Chun-juan,ZHOU Yong-da,ZHANG Jian-bo,TIAN Geng-yuan.Researches of polysaccharides from Achyrnthes bidentata[J].Chinese Journal of New Drugs,2006,15(16):1330-1334. |
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| Authors: | SHI Chun-juan ZHOU Yong-da ZHANG Jian-bo TIAN Geng-yuan |
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| Institution: | 1 Department of Chemistry, East China Normal University, Shanghai 2000621 China; 2 State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Sinica Academy of Sciences, Shanghai 200032, China |
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| Abstract: | Polysaccharides with hydrophile and easy absorption in vivo that are isolated from the root of Achyrnthes bidentata(AbPS)show immunomodulative activities.A series of polysaccharide deriva- tives by chemical modification of the mother structure,including sulfation,phosphorylation,carboxym- ethylation and hydroxyethylation,exhibit the more potent and innovative biological activities.This article overviews advances of AbPS with regard of the structure,isolation and pharmacological activities. |
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| Keywords: | Achyrnthes bidentata polysaccharide(AbPS) fructan physical and chemical properties pharmacological activity derivatives |
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