血清胱抑素C和MDRD方程在慢性肾脏病诊断中的临床应用

目的探讨血清胱抑素-C（Cys—C）在诊断慢性肾脏病（CKD）的意义，以及Cys-C与MDRD方程估计肾小球滤过率（GFR）的准确性及相关性。方法根据MDRD方程7计算的肾小球滤过率（GFR）将CKD患者分为5期，ELISA法检测CKD患者的Cys—C的水平，观察Cys—C与血肌酐（Scr）、GFR的相关性。结果Cys—C与Scr呈正相关，与GFR呈负相关；在肾功能轻度损伤时，Cys-C反映肾功能恶化程度的敏感度较Scr高。结论ELISA法能够检测Cys—C的水平，Cys—C能够作为反映肾功能的可靠指标，并且是肾功能的早期诊断指标。CKD2-5期，Cys—C与MDRD方程7有良好的相关性；Cys-C与MDRD方程7能够作为CKD2-5期患者估计GFR的指标。

Clinical diognostic value of serum Cystatin C and MDRD equation for chronic kidney disease

Objective To study the clinical value of Cys-C and MDRD equation in the patient with CKD.GFR was estimated by Cys-C and MDRD equation.To study the correlation between Cys-C and MDRD equation.Methods According to the value of GFR of the patient with CKD,divided them into five groups.To study the correlation between Cys-C and GFR.To explore the correlation between Cys-C and Sc.Results Cys-C was correlated with Scr.There was negative correlation between Cys-C and GFR.When renal function slightly injured,Cys-C was higher sensitivity than Scr.Conclusion It is reliable to detect Cys-C by enzyme linked immunosorbent assay(ELISA).It is dependable to judge renal function by the level of Cys-C.Cys-C can be a sensitive marker to reflect GFR.GFR was estimated by Cys-C and MDRD equation.It was correlation between Cys-C and MDRD equation.