吸烟与冠状动脉病变程度相关性的探讨

目的：探讨吸烟与冠状动脉病变程度的相关性，以加强吸烟的控制，深化冠心病一级预防理念。方法：回顾性分析北京大学人民医院心导管室的冠脉造影病例1302例，将其冠脉病变进行狭窄程度、病变范围及Gensini积分统计，分为病变组与无病变组，与其相应的15项危险因素组间行t检验、logistic多因素及线性回归分析。结果：两组之间男性、年龄、吸烟量、吸烟年限、高血压和糖尿病病程(t=2．6276～6．0983，P=0．0089～0．0001)，血浆胆固醇、甘油三酯、低密度脂蛋白(t=2．3146～5．5781，P=0．0212～0．0001)、高密度脂蛋白(t=-5.224，P=0．001)11项危险因素存在显著差异。吸烟量(OR=1．04，P=0．0001)、吸烟年限(OR=1．02，P=0．0001)、男性(OR=1．06，P=0．0001)是冠心病的独立危险因素。吸烟量及吸烟年限与冠状动脉狭窄程度、病变范围及Gensini积分呈正相关。结论：吸烟与冠状动脉病变程度是独立相关的。因此，应将控制吸烟作为冠心病的主要防治措施之一。

Correlation between Smoking and Severity of Coronary Lesions

Objective: To assess the correlation between smoking and coronary lesion. Methods: Coronary angiography was performed in 1302 patients whose coronary lesions were assessed by Gensini. Univariate analysis and logistic regression analysis were used to study the relationship between severity of coronary lesions and 15 factors including smoking. Results: The quanti-ty(OR = 1.04, P = 0.0001) and years(OR = 1.02, P = 0.0001) of smoking and male(OR = 1. 06, P = 0. 0001)were independent risk factors to the severity of coronary lesions. Positive correlations between smoking and severity of coronary lesions. Positive correlations between smoking and severity of coronary lesions. Conclusion: The study suggests there is independent correlation between smoking and coronary lesions. The restriction of smoking should be one of the key points to prevent and cure coronary artery disease.