Phosphoinositide 3-Kinase Is Involved in Mediating the Anti-inflammation Effects of Vasopressin |
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| Authors: | Woan-Ching Jan Ming-Chang Kao Chen-Hsien Yang Ya-Ying Chang Chun-Jen Huang |
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| Affiliation: | 1.Department of Nursing, Mackay Junior College of Medicine, Nursing and Management,New Taipei City,Taiwan;2.Department of Anesthesiology, Taipei Tzu Chi Hospital,Buddhist Tzu Chi Medical Foundation,New Taipei City,Taiwan;3.School of Medicine,Tzu Chi University,Hualien City,Taiwan |
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| Abstract: | Vasopressin possesses potent anti-inflammatory capacity. Phosphoinositide 3-kinase (PI3K) and its downstream activator Akt contribute to endogenous anti-inflammation capacity. We sought to elucidate whether PI3K is involved in mediating the anti-inflammation effects of vasopressin. Macrophages (RAW264.7 cells) were randomized to receive endotoxin, endotoxin plus vasopressin, or endotoxin plus vasopressin plus the nonselective PI3K inhibitor (LY294002) or the selective isoform inhibitor of PI3Kα (PIK-75), PI3Kβ (TGX-221), PI3Kδ (IC-87114), or PI3Kγ (AS-252424). Compared to macrophages treated with endotoxin, the concentrations of cytokines (tumor necrosis factor-α, interleukin-6) and chemokine (macrophage inflammatory protein-2) in macrophages treated with endotoxin plus vasopressin were significantly lower (all P?P?P?
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