Peripheral primitive neuroectodermal tumour of the cervix |
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| Authors: | P. Pauwels P. Ambros C. Hattinger M. Lammens P. Dal Cin J. Ribot A. Struyk H. van den Berghe |
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| Affiliation: | (1) Stichting PAMM, Catharina Ziekenhuis, Michelangelolaan 2, NL-5623 EJ Eindhoven, The Netherlands e-mail: lvpa@worldonline.nl Tel.: +31-40-2396119 Fax: +31-40-2396109, NL;(2) Department of Radiotherapy, Catharina Ziekenhuis, Eindhoven, The Netherlands, NL;(3) Department of Gynaecology, Catharina Ziekenhuis, Eindhoven, The Netherlands, NL;(4) Center for Human Genetics, University of Leuven, Leuven, Belgium, BE;(5) St. Anna Kinderspital, A-1090 Vienna, Austria, AT |
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| Abstract: | Peripheral primitive neuro-ectodermal tumours (PNET) of the cervix are very rare. Here, we report the clinical, pathological, immunohistochemical and genetic features of a case of a PNET located in the cervix. Hysterectomy revealed a cervical tumour. On microscopic examination, a vaguely lobular arrangement of uniformly appearing neoplastic cells, with round to oval nuclei, distinct nuclear membranes and a clear, moderately glycogen-rich cytoplasm was seen. Cells stained positive for LEU 7, S 100, monoclonal NSE and particularly for MIC2. Neurogenic differentiation was also seen by electron microscopic examination. The genetic hallmark of PNET, a 22q12 rearrangement was demonstrated by fluorescence in situ hybridisation experiments, supporting the diagnosis. Awareness of the existence of primary PNET of the cervix is important to avoid confusion with other tumours of the cervix. Received: 19 November 1998 / Accepted: 12 June 1999 |
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| Keywords: | Cervix Peripheral primitive neuroectodermal tumour Ewing’ s tumour pathology Immunohistochemistry Cytogenetics |
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