羊膜移植对于减少碱烧伤后角膜新生血管的临床研究

目的:观察羊膜移植手术对于减少碱烧伤后角膜新生血管的疗效.方法:回顾性病例对照研究.2006-2010年期间该院收治的Ⅲ度角膜碱烧伤的患者19例23眼,其中行羊膜移植术(治疗组)11例13眼,未行羊膜移植术(对照组)8例10眼.该两组的年龄和手术外的处理基本匹配.伤后3 d治疗组行羊膜移植术.分别在伤后14、60 d测量各组角膜新生血管面积.应用SPSS12.0统计学软件将此两组的面积进行配对t检验.以P<0.05作为差异有统计学意义.结果:在烧伤后14 d治疗组新生血管面积(62.133±8.571)mm2,明显低于对照组(89.561.4±9.741)mm2,治疗组较对照组减低30.6%,两组差异具有统计学意义(P<0.05).烧伤后60 d治疗组新生血管面积(112.019±17.362)mm2,明显低于对照组为(129.481±13.534)mm2,治疗组较对照组减低13.5%,两组差异具有统计学意义(P<0.05).结论:羊膜移植术能明显抑制碱烧伤所致角膜新生血管的生长.

Clinical study of the effect of amnion membrane transplantation on diminishing corneal neovascularization induced by alkali burn

PURPOSE:To study the curative effect of amnion membrane transplantation on decreasing corneal neovascularization(CNV) induced by alkali burn. METHODS:It was a non-randomized retrospective case-control study. Among 19 cases (23 eyes) of third-degree alkali burns from 2006 to 2010, 11 cases (13 eyes) were performed with amnion membrane transplantation operation, and others were not. Amnion membrane transplantation was performed at 3rd day after burns in the treatment group. Ages and treatments beyond surgery of double groups were matched. Areas of CNV in double groups were measured at the 14th and 60th days after burn. RESULTS：Area of CNV in the treatment group was (62.133±8.571) mm2 at the 14th day after burn, and was 30.6% lower than that in the control group. Area of CNV in the treatment group was (112.019±17.362)mm2 at the 14th day after burn, and was 13.5% lower than that in the control group. There was statistical significance between the two groups (P<0.05). CONCLUSION:Amnion membrane transplantation operation can inhibit the growth of corneal neovascularization induced by alkali burn.