~(18)F-FDG双探头符合电路SPECT鉴别诊断肺部良恶性病变

目的 评价双探头符合电路SPECT对~(18)F-FDG显像鉴别诊断肺部良恶性病变的临床价值。方法 15例肺癌及9例肺部良性病变患者进行了~(18)F-FDG双探头符合电路显像。空腹卧位肘前静脉注射5mCi~(18)F-FDG后1.5小时采集全身冠状面断层图像及胸、腹部三维断层图像。所有图像分别做视觉分析及ROI比值分析。仪器为PICKER分司AXIS双探头符合电路SPECT,图像重建采用迭代算法,不作穿透校正。结果 视觉分析时15例肺癌及2例良性病变阳性,其诊断肺癌灵敏度、特异性分别为100％、77.8％、ROI分析当设定R≥2.5为阳性判定标准时,灵敏度、特异性分别为100％、88.9％。同时在显像中发现35枚肺癌转移性淋巴结,其最小直径为1.0cm。结论 ~(18)F-FDG双探头符合电路SPECT显像能鉴别诊断肺部良恶性病变,诊断效能优于XCT,并与PET相似,此外它还可显示1.0cm及以上的转移性淋巴结。

~(18)F-FDG Dual head SPECT coincidence imaging in differentiating cancer and benign pulmoary disease

Purpose To evaluate the clinical value of dual head SPECT coincidence imaging in differentiating lung cancer from benign pulmonary disease. Methods 15 patinets with lung cancer and 9 patients with benign pulmonary disease underwent 18F - FDG coincidence imaging using dual head SPECT. Fasted in the morning, the patient was in supine position and injected 5mCi 18F- FDG into the anticubital vein. 1.5 hours after injection, whole body coronal tomography and thoracic, abdomen tomography were acquired. The machine is AXIS dual head coincidence SPECT of PICKER company, the acquired date were reconstructed using iterative algorithm and no transmission correction was used. Results 15 patients with lung cancer and 2 patients with benign pulmonary are positive in visual analysis,its sensitivity and specificity is 100% ,77.8% respectively,When R >2.5 is determinde to be diagnostic standard in ROI analysis, the sensitivity and specificity is 100% ,88.9% ,Meanwhile we found 35 metastatic lymph nodes, its smallest diameter is 1.0cm. Conclusion ' F - FDG dual head SPECT coincidence imaging can differentiate lung cancer from benign pulmonary disease. Its diagnostic efficiency is better than that of XCT, and very similar to that of PET. It also can detect metastatic lymph node 1.0cm or bigger than 1.0cm.