和胃化湿片治疗腹泻型肠易激综合征的临床研究

目的研究和胃化湿片治疗腹泻型肠易激综合征(IBS-D)的临床疗效。方法100例IBS-D患者,按照随机数字抽取法分为对照组及观察组,各50例。对照组给予常规治疗,观察组在对照组的基础上加用和胃化湿片治疗。比较两组患者治疗前后的焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分、肠易激综合征症状严重程度调查表(IBS-SSS)评分、中医证候积分,不良反应发生情况,复发情况。结果治疗后,两组患者的SAS、SDS评分均低于本组治疗前,且观察组患者的SAS评分(31.31±6.11)分、SDS评分(30.28±6.05)分均低于对照组的(53.13±6.18)、(52.73±6.08)分,差异均具有统计学意义(P<0.05)。治疗后,两组患者的腹痛不适、每10天腹痛发作天数、当天腹胀不适程度、对大便情况的满意度、肠道症状对生活的困扰评分及总分,腹痛、腹泻、大便次数、大便性状积分及总积分均低于本组治疗前,且观察组均低于对照组,差异均具有统计学意义(P<0.05)。两组患者的不良反应发生率比较,差异无统计学意义(χ^2=0.444,P>0.05)。观察组患者的复发率为4.0%,低于对照组的24.0%,差异具有统计学意义(χ^2=8.306,P<0.05)。结论和胃化湿片治疗IBS-D可有效改善临床症状,改善焦虑和抑郁状态,减少复发。

Clinical study of Hewei Huashi tablets in the treatment of diarrhea-predominant irritable bowel syndrome

Objective To study the clinical efficacy of Hewei Huashi tablets in the treatment of diarrhea-predominant irritable bowel syndrome(IBS-D).Methods A total of 100 IBS-D patients were divided into control group and observation group according to random numerical table,with 50 cases in each group.The control group received conventional therapy,and the observation group received Hewei Huashi tablets based on the control group.The self-rating anxiety scale(SAS)score,self-rating depression scale(SDS)score,irritable bowel syndrome symptom severity scale(IBS-SSS)score,scores of traditional Chinese medicine syndromes before and after treatment,occurrence of adverse reactions and recurrence of the two groups were compared.Results After treatment,SAS and SDS score of the two groups were lower than those before treatment,and SAS score(31.31±6.11)points and SDS score(30.28±6.05)points of the observation group were lower than(53.13±6.18)and(52.73±6.08)points of the control group,and the difference was statistically significant(P<0.05).After treatment,the abdominal pain and discomfort,number of days of abdominal pain every 10 days,degree of abdominal distension and discomfort that day,satisfaction with bowel conditions,intestinal symptoms on life trouble score and total score,abdominal pain,diarrhea,stool frequency,stool trait score and total score of the two groups were lower than those before treatment,and the observation group was lower than the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in incidence of adverse reactions between the two groups(χ^2=0.444,P>0.05).The recurrence rate of the observation group was 4.0%,which was lower than 24.0%of the control group,and the difference was statistically significant(χ^2=8.306,P<0.05).Conclusion Hewei Huashi tablets can effectively improve the clinical symptom,anxiety and depression,and reduce recurrence in the treatment of IBS-D.