预防性应用抗生素对肝硬化上消化道出血患者感染的影响

目的研究肝硬化上消化道出血患者预防性应用抗生素治疗的效果及对感染的影响。方法86例肝硬化上消化道出血患者,遵照双盲法分为对照组和观察组,各43例。对照组实施常规治疗方式,观察组在常规治疗的基础上预防性使用抗生素。比较两组临床指标、病死率与再出血率、感染情况。结果观察组止血时间(2.42±0.23)d、功能恢复时间(3.32±0.54)d、治疗时间(7.46±1.43)d,均短于对照组的(4.51±0.93)、(5.76±1.18)、(11.56±2.15)d,差异有统计学意义(P<0.05)。观察组病死率为0,再出血率为9.30%,均低于对照组的9.30%、25.58%,差异有统计学意义(P<0.05)。观察组总感染率为27.91%,低于对照组的48.84%,差异有统计学意义(P<0.05)。结论预防性应用抗生素在肝硬化上消化道出血患者中比常规治疗的作用更佳,对于抑制感染情况,预防患者消化道再次出血等有十分重要的意义。

Effect of prophylactic antibiotics on infection in patients with liver cirrhosis and upper gastrointestinal hemorrhage

Objective To study the effect of prophylactic antibiotics for patients with liver cirrhosis and upper gastrointestinal hemorrhage and its influence on infection.Methods A total of 86 patients with liver cirrhosis and upper gastrointestinal hemorrhage were divided into control group and observation group according to double-blind method,with 43 cases in each group.The control group was treated with conventional therapy,and the observation group was treated with prophylactic antibiotics on the basis of conventional medicine.The clinical indicators,case-fatality rate and rehemorrhage rate,and infection Status were compared between the two groups.Results The hemostasis time(2.42±0.23)d,function recovery time(3.32±0.54)d and treatment time(7.46±1.43)d of the observation group were shorter than(4.51±0.93),(5.76±1.18)and(11.56±2.15)d of the control group,and the difference was statistically significant(P<0.05).The case-fatality rate and rehemorrhage rate of the observation group was 0 and 9.30%,which were lower than 9.30%and 25.58%of the control group,and the difference was statistically significant(P<0.05).The total infection rate of the observation group was 27.91%,which was lower than 48.84%of the control group,and the difference was statistically significant(P<0.05).Conclusion Prophylactic antibiotics is better than conventional treatment in patients with upper gastrointestinal hemorrhage,and it is of great significance for inhibiting infection and preventing the patient’s gastrointestinal hemorrhage.