应用罗沙司他治疗肾性贫血对患者微炎症因子的影响

目的 探讨肾性贫血患者采取罗沙司他治疗对其微炎症因子的影响.方法 40例肾性贫血患者,依据系统抽样法分为对照组与观察组,各20例.对照组采用重组人促红细胞生成素(rHuEPO)治疗,观察组采用罗沙司他治疗.对比两组患者治疗前后转铁蛋白饱和度(TSAT)、血清铁蛋白(SF)、血红蛋白(HGB)及血细胞比容(HCT)及治疗...

Effect of roxadustat on the microinflammatory factors in patients with renal anemia

Objective To discuss the effect of roxadustat on microinflammatory factors of patients with renal anemia.Methods A total of 40 patients with renal anemia as study subjects were divided into control group and observation group according to systematic sampling method,with 20 cases in each group.The control group was treated with recombinant human erythropoietin(rHuEPO),and the observation group was treated with roxadustat.The transferrin saturation(TSAT),serum ferritin(SF),hemoglobin(HGB),hematocrit(HCT)before and after treatment,and interleukin-6(IL-6)and C-reactive protein(CRP)levels after treatment were compared between the two groups.Results After treatment,TSAT(31.59±1.36)%,SF(267.95±41.48)μg/L,HGB(117.24±29.45)g/L and HCT(28.63±2.34)%of the observation group were higher than(25.34±1.62)%,(226.35±41.15)μg/L,(98.47±26.34)g/L and(25.12±2.06)%of the control group,and the difference was statistically significant(P<0.05).After treatment,IL-6(63.37±12.59)pg/ml and CRP(51.23±13.21)mg/L of the observation group were lower than(113.32±48.69)pg/ml and(59.52±12.56)mg/L of the control group,and the difference was statistically significant(P<0.05).Conclusion Roxadustat has a high application value during the treatment of renal anemia,and it can significantly reduce inflammation in addition to improving anemia indicators,which is worthy of adoption and promotion.