分析绝经后骨质疏松症应用阿仑膦酸钠与激素替代疗法的治疗效果

目的 分析绝经后骨质疏松症应用阿仑膦酸钠与激素替代疗法治疗的临床效果.方法 70例绝经后骨质疏松症患者作为研究对象,依据随机数字表法分为对照组与观察组,每组35例.对照组患者口服替勃龙治疗,观察组患者口服阿仑膦酸钠治疗.比较两组患者骨密度、临床疗效与雌二醇(E2)、促卵泡生成素(FSH)水平.结果 治疗前,对照组患者的...

Analysis of the effect of alendronate sodium and hormone replacement therapy on postmenopausal osteoporosis

Objective To analyze the clinical effect of alendronate sodium and hormone replacement therapy on postmenopausal osteoporosis.Methods A total of 70 patients with postmenopausal osteoporosis as study subjects were randomly divided into control group and observation group,with 35 cases in each group.The control group was treated with tibolone orally,while the observation group was treated with alendronate sodium orally.The bone mineral density,clinical efficacy,estradiol(E2),follicle stimulating hormone(FSH)levels were compared between the two groups.Results Before treatment,the bone density of the lumbar spine 1-4 and the bone density of the right femoral neck of the control group were(0.820±0.020)and(0.746±0.019)g/cm^2,which were(0.821±0.020)and(0.745±0.021)g/cm^2 of the observation group.After treatment,the bone density of the lumbar spine 1-4 and the bone density of the right femoral neck of the control group were(0.851±0.018)and(0.764±0.022)g/cm^2,which were(0.856±0.014)and(0.762±0.018)g/cm^2 of the observation group.After treatment,the bone density of the lumbar spine 1-4 and right femoral neck of the two groups were better than those before treatment,and the difference was statistically significant(P<0.05).After treatment,there was no statistically significant difference in bone density of the lumbar spine 1-4 and right femoral neck between the two groups(P>0.05).The total effective rate of treatment of the observation group was 100%,which had no statistically significant difference compared with 100%of the control group(P>0.05).Before treatment,E2 and FSH of the control group were(32.04±25.08)pg/ml,and(72.54±32.08)mIU/ml,which were(33.54±29.10)pg/ml and(69.09±27.08)mIU/ml of the observation group.After treatment,E2 and FSH of the control group were(64.32±28.54)pg/ml and(45.08±25.27)mIU/ml,which were(33.62±22.08)pg/ml and(71.04±22.42)mIU/ml of the observation group.After treatment,E2 of the control group was higher that that before treatment,and FSH was lower than that before treatment,and the difference was statistically significant(P<0.05).After treatment,E2 and FSH of the observation group had no statistically significant difference compared with those before treatment(P>0.05).Conclusion Both alendronate and hormone replacement therapy can effectively increase the bone mineral density of patients with postmenopausal osteoporosis,but compared with hormone replacement therapy,alendronate has less effect on patients’serum E2 and FSH levels.