Difficulties in Immunohaematology : The Weak D Antigen |
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Authors: | H Kumar DK Mishra RS Sarkar M Jaiprakash |
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Affiliation: | *Associate Professor, Department of Transfusion Medicine, AFMC, Pune;+Classified Specialist (Pathology and Haematology), AHDC(R&R), Delhi Cantt;#Cl Spl (Path & Haem) MH Roorkee;**Professor and Head, Department of Transfusion Medicine, AFMC, Pune |
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Abstract: | BackgroundThe Rh blood system is one of the most polymorphic and immunogenic systems known to humans. The expression of Rh blood group antigen is complex. The Rh D antigen is the most important of the antigens that constitute the Rh antigen system. In most cases, D antigen can easily be detected. However, due to variability of expression, weak forms antigen are encountered. The reactivity of weak D with antisera is variable and presents as a problem in blood banking.MethodsA retrospective analysis for a five-year period was done. Blood samples that were negative for Rh D by immediate spin tube method were tested for weak D antigen by additional lab tests.ResultOf 34932 serial Rh grouping tests done in our Blood Bank, the incidence of weak D Rh antigen was 0.189%. All these were confirmed by the antiglobulin test.ConclusionThese patients present as a problem for the blood banker and a curiosity to the clinician. Although uncommon, all health care workers should be aware of this entity to avoid anti D alloimmunisation.Key Words: Weak D, Rh Blood Group |
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Keywords: | Weak D Rh Blood Group |
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