特异性IgA抗体: 心脑血管病慢性肺炎衣原体感染的标志

目的：探索心脑血管病慢性肺炎衣原体（ＣＰ）感染的血清学证据。

Specific immunoglobulin A: a markers of chronic chlamydia pneumoniae infection in cardiovascular and cerebrovascular diseases

Objectives: To seek serological evidence of chronic infection with chlamydia pneumoniae(CP)in cardiac and cerebral vascular diseases. Methods: Using microimmunofluorescence(MicroIF)method to determine immunoglobulin(Ig) classspecific antibodies to CP in serum. Results: 37% of the patients with cardiac and cerebral vascular diseases had elevated titers(1 in 32 or over) of serum specific CP IgA antibodies. Both frequencies were significantly higher than the controls(donors, 3%), but serum specific CPIgG and CPIgM antibodies did not differ from the controls(donors). Conclusions: An association exists between chronic CP infection and serum specific CPIgA antibodies and no association exits in serum specific CPIgG and CPIgM antibodies. Serum specific CPIgA antibodies were markers of chronic cp infection which can be used in the diagnosis and scientific research of the relationship between chronic cp infection(carrier) and cardiac or cerebral vascular and other diseases.