特发血小板减少性紫癜患者血小板平均容积检测的临床价值

目的观察特发血小板减少性紫癜(ITP)患者血小板平均体积(MPV)、血小板平均分布宽度(PDW)、大血小板比率(P-LCR)及血小板计数(Plt)的动态变化,并探讨其相关的临床意义。方法收集我院2011年6月~2013年1月诊治的特发性血小板减少性紫癜患儿88例,另取我院保健门诊体检的健康儿童40例作为对照,全自动血细胞分析仪检测各样本Plt、MPV、PDW及P-LCR血小板参数的变化。结果对照组Plt显著高于ITP组(P<0.01),而对照组MPV、PDW及P-LCR显著低于ITP组(P<0.01)。Plt、MPV、PDW及P-LCR血小板参数在轻度组、中度组、重度组之间存在显著性差异(P<0.05),Plt会随着病情的加重逐渐减低(P<0.05),然而MPV、PDW及PLCR则随着病情的加重逐渐升高(P<0.05)。ITP患者治疗后Plt较治疗前显著升高(P<0.01),而MPV、PDW及PLCR则显著减低(P<0.01)。结论 Plt、MPV、PDW及P-LCR血小板参数的检测有助于ITP的鉴别诊断、病情判断及疗效观察。

The detection of MPV in patients with idiopathic thrombocytopenic purpura

Objective To investigate the clinical efficacy of MPV, PDW, P-LCR, and Pit in patients with idiopathic thrombocytopenic purpura （ITP）. Methods A total of 88 children with ITP were enrolled in this study. Another 40 healthy children were used as control. the MPV, PDW, P-LCRD, and Pit were detected by Sysmex XE-2100. Re- suits The Plt was higher in control group than that in ITP group （P〈0.01）. However, the MPV, PDW, and P-LCRD was lower in control group than that in ITP group （P〈0.01）. There was significant difference of Plt, MPV, PDW and P-LCR among mild, middle, and severe group（P〈0.05）. Compared before treatment, Ph was increased after treatment （P〈0.01）, and MPV, PDW, and P-LCRD was decreased（P〈0.01 ）. Conclusion Ph, MPV, PDW, and P-LCR play a key role in diagnosis and prognosis of ITP, or observing the effectiveness of therapy of ITP.