透明质酸钠预防人工流产术后宫腔粘连效果评价

目的探讨人工流产术后应用透明质酸钠预防宫腔粘连的临床效果。方法选择2011年9月~2012年12月在我院行人流手术的患者420例,分为观察组和对照组各210例;对照组行人工流产术后常规口服抗生素预防感染;观察组于手术结束时经宫颈管注入透明质酸钠凝胶2mL,同时口服抗生素预防感染。比较两组术后腹痛持续时间、阴道流血时间、月经恢复、宫腔粘连等情况。结果观察组腹痛持续时间为(26.38±8.45)min、阴道流血时间为(4.36±1.32)d、术后出血量为(42.78±10.63)mL,均明显低于对照组的(37.19±8.97)min、(6.28±2.23)d、(55.89±13.05)mL。两组比较差异有统计学意义(P<0.05)。观察组术后月经恢复时间为(28.37±3.56)d,明显早于对照组的(32.56±5.32)d,周期性腹痛17例(8.10%),对照组周期性腹痛49例(23.33%),小于对照组;观察组宫腔粘连发生4例(1.90%),对照组粘连发生19例(9.05%),观察组粘连发生率明显低于对照组,且观察组术后无感染发生,两组比较差异均有统计学意义(P<0.05)。结论人工流产术后应用透明质酸钠预防宫腔粘连效果较好,值得临床推广应用。

Effect of sodium hyaluronic acid on preventing intrauterine adhesions caused by induced abortion

Objective To explore the effect of sodium hyaluronic acid on preventing intrauterine adhesions caused by induced abortion. Methods From September 2011to December 2012, a total of 420 cases of pregnant womert treated by induced abortion in our hospital were divided into observation group and control group, each of 210 cases. Control group with oral antibiotics to prevent infection after induced abortion. At the end of operation via the observation group was injected injection of sodium hyaluronate 2mLthrough the cervix tube, and oral antibiotics to prevent infection as well. The time of persistent abdominal pain, the time of vaginal bleeding, the resumption of the situation of menstruation, and intrauterine adhesions were compared. Results The time of abdominal pain duration were （26.38 ±8.45） minutes in observation group, the time of vaginal bleeding were （4.36_±1.32） days, the post operation blood loss was（42.78± 10.63 ） mL, all significantly lower than （37.19±8.97） minutes, （6.28±2.23） days, （55.89± 13.05） mL in the control group, difference between the two groups had statistical significance （P 〈 0.05）. The time of menstruous restoration in observation group after abortions was （28.37±3.56） days, obviously earlier than the control group （32.56±5.32） days, 17 cases （8.10%） with periodic hypogastralgia in observation group, less than the control group 49 cases （23.33%）; Four cases （1.90%） with intrauterine adhesionsin in observation group, while 19 cases （9.05%） in control group, the rate of intrauterine adhesions in observation group was lower than the control group, none cases without postoperative infection in the observation group, difference between the two groups had statistical significance （/9 〈 0.05）. Conclusion The effect of sodium hyaluronic acid on preventing intrauterine adhesions caused by induced abortion was good, it is worth to be applied and extended in the clinical.