丁苯酞（恩必普）联合丹参治疗缺血性脑卒中的临床疗效观察

目的探讨丁苯酞（恩必普）联合丹参治疗缺血性脑卒中的临床疗效。方法选取缺血性脑卒中患者60例，随机分为观察组和对照组各30例，两组均予吸氧、降颅内压、降血糖、抗血小板凝聚、降血脂等对症支持治疗，对照组予丹参注射液20～40mL加入5％葡萄糖注射液250mL中静滴，每日1次，2周一疗程。观察组在对照组的基础上联用丁苯酞软胶囊，每次2粒口服，每日3次，2周一疗程，比较两组患者的疗效及治疗前后NIHSS评分的变化。结果治疗14d后，两组患者的NIHSS评分均较治疗前明显降低（P〈0．05）；且观察组患者治疗后的NIHSS评分较对照组明显降低（P〈0．05）；治疗14d后观察组的基本痊愈率达33-3％、总有效率达90．0％、对照组的基本痊愈率23．3％、总有效率70．0％，两组总有效率比较，差异有统计学意义（χ2=6．376，P〈0．05）。结论丁苯酞（恩必普）联合丹参治疗缺血性脑卒中可以提高临床疗效，改善患者的临床症状，值得推广和应用。

Clinical efficacy of NBP combined with Salvia in treatment of ischemic stroke

Objective To investigate the efficacy of NBP combined Salvia in treatment of ischemic stroke. Methods A total of 60 patients with ischemic cerebrovascular death were randomly divided into observation group and control group of 30 patients, two groups were given oxygen, reduced intracranial pressure, lowered blood sugar, anti-platelet aggrega- tion, regulated of cholesterol and other symptomatic and supportive treatment ,the control group was given Salvia injec- tion 20-40 mL 5% glucose injection 250 mL infusion, once day, 2 weeks for treatment. The observation group on the basis of the control group associated with Butylphthalide every two soft capsules, 3 times a day , orally, two weeks for a course,treatment efficacy and NIHSS score after treatment were compared. Results After treatment 14 days , the ob- servation group and control group patients NIHSS scores were significantly lower than before treatment （P 〈0.05 ）, re- spectively ; and after treatment NIHSS score of observation group was significantly lower than the control group （P 〈 0.05）; After treatment 14 days, the total effective rate of the observation group was 90.0% , the total effective rate of control group was 70.0%, the difference was statistically significant （χ2=6.376,P 〈0.05）. Conclusion Butylphthalide combined Salvia in treatment of isehemic stroke gastrodin can improve clinical outcomes and improve clinical symp- toms, should be promoted and applied.