乌司他丁对脓毒症患者血清炎症因子的影响及疗效观察

目的 探讨乌司他丁对脓毒症患者血清IL-6、IL-10、IL-1β的影响及疗效.方法 将66例脓毒症患者随机分为研究组和对照组.两组予以针对基础疾病治疗及抗感染、对症和营养支持等治疗.研究组加用乌司他丁20万U静滴,2次/d,对照组予以等量生理盐水静滴.结果 治疗7d后,两组血清IL-6和IL-1β水平明显下降,IL-10水平明显上升,且研究组下降或上升值明显大于对照组.研究组和对照组总有效率分别为90.91％和66.67％,两组比较差异有统计学意义.研究组和对照组出现分别不良反应4例和2例,差异无统计学意义.结论 乌司他丁治疗脓毒症疗效显著,安全性佳,其效果与抑制促炎因子IL-6、IL-1β的释放和促进抑炎因子IL-10释放密切相关.

Influence and efficacy of ulinastatin on serum inflammatory factors of patients with sepsis

Objective To investigate the influence and efficacy of ulinastatin on serum interleukin-6, 10 and 113 of pa- tients with metastasizing septicemia. Methods Sixty-six cases of patients with metastasizing septicemia were divided into research group and control group at random. The patients in two groups were given basic and routine medical treat- ment such like sensitive antibiotics, anti-infection, nutrition support and etc. Based on routine medical treatment, the patients in research group were additionally given 200 000 U ulinastatin 2 times per day, while the patients in control group were given the equal amount of normal saline. Results After medical treatment for 7 days, the serum IL-6 and 1β levels of patients in two groups declined obviously than before, while serum IL-10 level rose obviously than before, and the declining or rising rate in research group was much higher than those in control group. The total clinical effi- ciency rates of patients in research group and control group were 90.91% and 66.67% respectively, and there were sig- nificant curative effect differences. 4 and 2 cases of untoward effect appeared in research group and control group dur- ing the medical treatment period respectively. After comparing the occurrence rates of DAR, no statistical difference appeared. Conclusion Ulinastatin has reliable and significant curative effect on patients with metastasizing septicemia with high security, whose curative effect has close relationship with inhibiting the release of proinflammatory cytokines IL-6 and -1β and accelerating the release of proinflammatory cytokines IL-10.