右美托咪定预防高血压患者全麻苏醒期躁动和心血管反应的临床观察

目的探讨右美托咪定用于预防高血压患者全身麻醉苏醒期躁动和心血管不良反应的临床效果。方法将60例既往有高血压病史、拟在气管内插管静吸全麻下行择期腹部手术的患者(ASAⅡ~Ⅲ级),随机分为右美托咪定组(D组,n=30)和对照组(C组,n=30)。D组于手术结束前60 min经静脉微量注射泵泵注0.8μg/kg的右美托咪定,20 min注射完毕;C组注射等量的0.9%氯化钠溶液。结果 D组拔管即刻和拔管后各时间段的HR、SBP、DBP明显低于对照组(P<0.01),躁动和疼痛发生率也明显降低(P<0.01)。结论高血压患者全身麻醉中使用0.8μg/kg的右美托咪定能够显著减轻其苏醒期躁动和心血管反应,保持血流动力学稳定。

Clinical observation of dexmedetomidine in prevention of agitation and cardiovascular response after general anesthesia in patients with hypertension

Objective To investigate the effect of dexmedetomidine in prevention of agitation and cardiovascular re- sponse after general anesthesia in the patients with hypertension. Methods Sixty ASA 11 ~ Ill patients with hypertension scheduled for gastrointestinal surgery under general anesthesia were randomly divided into the dexmedetomidine group （group D, n=30） and the control group（group C, n=30）. At 60 minutes before the end of operation, dexmedetomidine 0.8 Ixg/kg was infused in group D within 20 minutes. Results HR, SBP and DBP in group D were significantly lower in the moment of extubation and after extubation than group C （P〈0.01）. Agitation and pain rate in groud D was significantly lower（P〈0.01）. Conclusion Dexmedetomidine 0.8 ~g/kg used for the patients with hypertension after general anesthesia can effectively reduce agitation and cardiovascular response and stabilize the bemodynamies status.