| KIR2DL1和KIR2DL3在炎症性肠病患者外周血和肠组织中的表达 |
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| 引用本文： | 黎文华,郑萍,刘占举.KIR2DL1和KIR2DL3在炎症性肠病患者外周血和肠组织中的表达[J].胃肠病学,2011,16(2):82-85. |
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| 作者姓名： | 黎文华 郑萍 刘占举 |
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| 作者单位： | 1. 上海交通大学附属第一人民医院消化内科,200080
2. 同济大学附属第十人民医院胃肠内科 |
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| 摘 要： | 背景：KIR2DL1和KIR2DL3属抑制性杀伤细胞免疫球蛋白样受体家族成员,在一些免疫相关疾病中发挥重要作用.目前,KIR2DL1和KIR2DL3在炎症性肠病（IBD）中的研究还相对较少.目的：探讨KIR2DL1和KIR2DL3在IBD患者外周血和肠组织中的表达及其临床意义.方法：收集111例溃疡性结肠炎（UC）患者、101例克罗恩病（CD）患者和110例健康志愿者.以聚合酶链反应-序列特异性引物（PCR-SSP）法检测外周血中KIR2DL1和KIR2DL3表达,并分析其与患者临床特征的关系.以免疫组化染色检测肠组织中KIR2D L1蛋白表达.结果：UC组外周血KIR2DL1和KIR2DL3表型频率均显著低于正常对照组（P＜0.05）;CD组KIR2DL1表型频率显著低于正常对照组（P=0.026）,但两组KIR2DL3表型频率无明显差异（P＞0.05）.KIR2D L1和KIR2DL3表型频率与UC和CD患者的疾病活动性、病情严重程度和病变部位均无关.UC和CD患者肠组织中KIR2DL1蛋白表达均明显低于对照组（P＜0.001）.结论：IBD患者中存在KIR2DL1基因和蛋白的低表达,提示其在IBD的免疫发病机制中可能起重要作用.
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| 关 键 词： | 结肠炎，溃疡性 Crohn病 杀伤细胞免疫球蛋白样受体 杀伤细胞，天然 |
Expressions of KIR2DL1 and KIR2DL3 in Peripheral Blood and Intestinal Tissue in Patients with Inflammatory Bowel Disease |
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| LI Wenhua,ZHENG Ping,LIU Zhanju.Expressions of KIR2DL1 and KIR2DL3 in Peripheral Blood and Intestinal Tissue in Patients with Inflammatory Bowel Disease[J].Chinese Journal of Gastroenterology,2011,16(2):82-85. |
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| Authors: | LI Wenhua ZHENG Ping LIU Zhanju |
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| Institution: | LI Wenhua,ZHENG Ping,LIU Zhanju.Department of Gastroenterology,The First People's Hospital,Shanghai Jiaotong University,Shanghai(200080) |
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| Abstract: | Background: KIR2DL1 and KIR2DL3 are members of inhibitory killer cell immunoglobulin-like receptor family,which play important roles in some immune-associated diseases.However,there are only few studies on KIR2DL1 and KIR2DL3 expressions in inflammatory bowel disease(IBD).Aims: To investigate the expressions and clinical significances of KIR2DL1 and KIR2DL3 in peripheral blood and intestinal tissue in patients with IBD.Methods: One hundred and eleven patients with ulcerative colitis(UC),101 Crohn's disease(... |
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| Keywords: | Colitis Ulcerative Crohn Disease Killer Cell Immunoglobulin-Like Receptors Killer Cells Natural |
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