| 食管癌患者外周血淋巴细胞亚群分析 |
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| 引用本文： | 王长春,凌志强,毛伟敏. 食管癌患者外周血淋巴细胞亚群分析[J]. 胃肠病学, 2011, 16(2): 103-105. DOI: 10.3969/j.issn.1008-7125.2011.02.010 |
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| 作者姓名： | 王长春 凌志强 毛伟敏 |
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| 作者单位： | 1. 浙江省肿瘤医院,浙江省肿瘤研究所,310022;浙江省立同德医院胸外科
2. 浙江省肿瘤医院,浙江省肿瘤研究所,310022 |
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| 基金项目： | 浙江省科技计划资助项目 |
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| 摘 要： | 背景：食管癌患者外周血淋巴细胞亚群与临床病理参数的相关性尚存在争议.目的：分析食管癌患者外周血淋巴细胞亚群的变化情况.方法：以流式细胞术检测食管癌荷瘤组（n=207）、非荷瘤组（n=33）和正常对照组（n=96）的外周血淋巴细胞亚群,并与临床病理参数行相关性分析.结果：荷瘤组患者外周血CD3＋、CD4＋、CD8＋、CD19＋细胞比例较正常对照组明显下降（P＜0.01或P＜0.05）,CD4＋/CD8＋比值、CD25＋、CD44＋、自然杀伤细胞比例较正常对照组明显升高（P＜0.01）.Ⅰ/Ⅱ期与Ⅲ/Ⅳ期、低分化与中分化、淋巴结阴性与阳性亚组间外周血淋巴细胞亚群差异无统计学意义（P＞0.05）.非荷瘤组患者外周血CD3＋、CD4＋细胞比例与正常对照组相比差异无统计学意义（P＞0.05）,其余淋巴细胞亚群比例与正常对照组相比差异有统计学意义（P＜0.05）.结论：食管癌患者外周血淋巴细胞亚群比例明显异常,提示机体免疫系统紊乱,但与肿瘤临床分期和恶性程度并不相关：食管癌患者的免疫功能于术后第3-4周开始恢复,CD3＋、CD4＋细胞是早期监测食管癌患者机体免疫状态的敏感指标.
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| 关 键 词： | 食管肿瘤 淋巴细胞：流式细胞术 |
Analysis of Peripheral Blood Lymphocyte Subsets in Patients with Esophageal Carcinoma |
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| WANG Changchun,LING Zhiqiang,MAO Weimin. Analysis of Peripheral Blood Lymphocyte Subsets in Patients with Esophageal Carcinoma[J]. Chinese Journal of Gastroenterology, 2011, 16(2): 103-105. DOI: 10.3969/j.issn.1008-7125.2011.02.010 |
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| Authors: | WANG Changchun LING Zhiqiang MAO Weimin |
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| Affiliation: | WANG Changchun,LING Zhiqiang,MAO Weimin.Zhejiang Province Cancer Hospital,Zhejiang Cancer Research Institute,Hangzhou(310022) |
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| Abstract: | Background: The correlation between peripheral blood lymphocyte subsets and clinicopathological parameters in patients with esophageal cancer is still controversial.Aims: To analyze the changes of peripheral blood lymphocyte subsets in patients with esophageal carcinoma.Methods: Flow cytometry was conducted to determine the peripheral blood lymphocyte subsets in patients with(n=207) or without(n=33) esophageal carcinoma and normal controls(n=96),and their correlations with clinicopathological parameters wer... |
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| Keywords: | Esophageal Neoplasms Lymphocytes Flow Cytometry |
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