Bupropion SR vs placebo for smoking cessation in health care professionals |
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Authors: | Zellweger Jean-Pierre Boelcskei Pal Laszio Carrozzi Laura Sepper Ruth Sweet Ruth Hider Amy Z |
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Institution: | University Medical Policlinic, 10011 Lausanne, Switzerland. zellwegerjp@swissonline.ch |
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Abstract: | OBJECTIVE: To evaluate bupropion SR for smoking cessation in physicians and nurses. METHODS: This double-blind prospective 26-center, 12-country trial randomized 687 subjects to smoking cessation counselling with bupropion SR or placebo for 7 weeks. The participants were followed for 52 weeks. RESULTS: Bupropion SR was superior to placebo (50% vs 40%, P=0.013) on the 4-week primary outcome variable. Due to a high placebo response in this health care population, statistical differences were not maintained after treatment was discontinued. CONCLUSIONS: Bupropion SR is effective and well tolerated in health care professionals. Relapse prevention measures are needed to attain long-term abstinence. |
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