Local degradation of luteinizing hormone-releasing hormone (LH-RH) in the rat central nervous system |
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| Authors: | E.C. Griffiths R. Forbes S.L. Jeffcoate D.T. Holland |
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| Affiliation: | 1. Department of Physiology, Stopford Building, University of Manchester, Manchester M13 9PT Great Britain;2. Department of Chemical Pathology, St. Thomas''s Hospital, London SE1 7EH Great Britain |
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| Abstract: | Peptidases inactivating luteinizing hormone-releasing hormone (LH-RH) were found to be present in two subcellular fractions prepared from the following areas of the central nervous system of male and female rats: thalamus, hypothalamus, cortex and cerebellum. LH-RH immunoreactivity was also detected in these fractions after peptidase activity had been removed by heat denaturation. These findings support the concept that LH-RH may have a role in modulating neuronal activity within the central nervous system (CNS). |
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