Effects of drugs on the characteristics of cat's saccadic eye movements

Eye movements were measured in concious adult cats with 4 previously implanted electro-oculographic (EOG) electrodes. Saccade characteristics were studied after parentoral administration of amphetamines, diazepam and pentothal. Control parameters were obtained in cats before drugs administration. Pentothal increases duration and decreases maximum velocity of saccades. These observations resemble those observed in men under fatigue and in drowsy animals. A possible relation between pentothal effects and saccadic movements impairment observed in certain cerebellar neurologic diseases is discussed. Amphetamines greatly modify maximum velocity of saccades in a way similar to that observed in increased alertness states. Diazepam has a weak effect on spontaneous saccades and this is similar to that observed in animals with a little decrease in the level of alertness.