新风胶囊对活动期类风湿关节炎的疗效及其对抑郁情绪的影响

目的 观察中药新风胶囊(XFC)对类风湿关节炎(RA)的疗效及其对抑郁情绪的影响,探讨其作用机制.方法 60例RA患者随机分成2组,治疗组35例采用XFC,对照组25例采用风湿骨痛胶囊,观察2组的临床疗效、主要症状体征、生活质量积分、SDS标准分等指标的变化.结果 XFC在总有效率、改善症状体征、活动性指标等方面与风湿骨痛胶囊相似,但治疗组显效率高于对照组,在改善SDS标准分、脾虚症状、生活质量积分方面优于风湿骨痛胶囊对照组(P＜0.05或P＜0.01).结论 XFC在取得疗效的同时,可改善RA患者抑郁情绪,提高生活质量.提示XFC调节内分泌失调、提高机体免疫功能等整体调节可能是其作用机制.

Effects of Xinfeng Capsule on Rheumatoid Arthritis in Active Phase and Depressive Mood

Objective To observe effects of Xinfeng capsule(XFC) on rheumatoid arthritis(RA) in active phase and depressive mood,and study its mechanism.Methods 60 RA patients were randomly divided into two groups,the treatment group(n=35) was treated with XFC,and the control group(n=25) with Fengshigutong capsule.The observation targets included clinical effects,presenting symptom and objective sign,integral calculus of quality of life,self-rating depression scale(SDS),etc..Results The effects of XFC were similar to that of Fengshigutong capsule in the total effective rate,improving symptoms and sign,active index,etc.,but the excellence rate of XFC exceeded the control group(P<0.05),the effect of XFC was superior to Fengshigutong capsule in improving SDS standard score,the symptoms of splenic asthenia(P<0.05 or P<0.01).Conclusion XFC has significant effect on treating RA,meanwhile it could improve depressive mood.Its mechanism is probably related with the effect of regulating endocrine disturbance and increasing organism immune function in RA patients.