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In vivo potentiation of cis-diamminedichloroplatinum (II) antitumor activity by pretreatment with sparsomycin
Authors:Z Zylicz  D J Wagener  H van Rennes  J M Wessels  E van der Kleijn  W J de Grip  H C Ottenheijm  L A van den Broek
Affiliation:1. Department of Critical Care & Respiratory Care Research, University of Texas MD Anderson Cancer Center, Houston, TX, United States;2. Department of Psychology & Neuroscience, The Center for Neuroscience, University of Colorado, Boulder, CO, United States;1. Cell and Molecular Biology Laboratory, Department of Zoology, Soban Singh Jeena University, Campus Almora, Uttarakhand, India;2. Department of Zoology, Kumaun University, Nainital, Uttarakhand, India;1. Department of Natural Sciences, School of Science and Technology, University of Georgia, Tbilisi 0171, Georgia;2. Department of Biochemistry and Microbiology, University of Chemistry and Technology, Technická 5, Prague 166 28, Czech Republic;3. Faculty of Exact and Natural Sciences, Ivane Javakhishvili Tbilisi State University, Tbilisi 0179, Georgia;4. Department of Materials and Metallurgical Engineering, Amirkabir University of Technology, Tehran, Iran;5. Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran;6. School of medicine, Shiraz University of Medical Sciences (SUMS), Shiraz, Iran
Abstract:The influence of protein synthesis inhibition by sparsomycin (Sm) on in vivo cisplatin activity has been studied on BALBc X DBA2: F1 mice bearing L1210 leukemia i.p. Sm alone at the dose range from 0.5 to 3.0 mg/kg did not significantly improve animal survival. Sm potentiated cisplatin activity only when given 3 or 6 h prior to cisplatin (P less than 0.001). Sm 0.5-1.5 mg/kg 3 h prior to cisplatin resulted in a significant prolongation of animal survival (P less than 0.001) and 66% cures in each group versus 0% due to cisplatin alone. Sm pretreatment decreased weight loss due to cisplatin suggesting that it probably is able to decrease cisplatin toxicity.
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