| 绞股蓝对小鼠一过性高尿酸血症的作用 |
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| 引用本文： | 李红琴,杨婧梅,高山,赵敏,胡继鹰. 绞股蓝对小鼠一过性高尿酸血症的作用[J]. 湖北中医药大学学报, 2010, 12(1): 14-15 |
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| 作者姓名： | 李红琴 杨婧梅 高山 赵敏 胡继鹰 |
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| 作者单位： | 湖北中医学院,湖北武汉,430061;湖北中医学院基础医学院,湖北武汉,430065 |
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| 基金项目： | 湖北中医学院大学生创新研究项目(2008J002) |
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| 摘 要： | 目的观察绞股蓝对实验性雄性小鼠一过性高尿酸血症的作用。方法将60只雄性小鼠随机分成6组,生理盐水组、模型组、对照组、绞股蓝大剂量组、绞股蓝中剂量组、绞股蓝小剂量组,分别以生理盐水、别嘌醇片和绞股蓝灌胃,连续10d。末次给药后,除生理盐水组外其余组腹腔注射次黄嘌呤0.63g/kg造模,之后测定小鼠血尿酸值及小鼠肝脏XOD的活性。结果血尿酸水平和肝脏组织XOD活性:绞股蓝中剂量组、别嘌呤醇组与模型组比较,差异均有非常显著性意义(P0.01)。结论绞股蓝对小鼠一过性高尿酸血症具有明显降低血尿酸水平的作用。
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| 关 键 词： | 绞股蓝 一过性高尿酸血症 尿酸 |
Effects of Gynostemma on Transient Hyperuricemia in Mice |
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| LI Hongqin,YANG Jingmei,GAO Shan,ZHAO Min,HU Jiying. Effects of Gynostemma on Transient Hyperuricemia in Mice[J]. Journal of Hubei University of Chinese Medicine, 2010, 12(1): 14-15 |
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| Authors: | LI Hongqin YANG Jingmei GAO Shan ZHAO Min HU Jiying |
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| Affiliation: | 1.Grade 2004 student of 7 year programme;Hubei University of Chinese Medicine;Wuhan 430061;Hubei;2.College of Fundamental Medicine;Wuhan 430065;Hubei |
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| Abstract: | Objective To observe the effects of gynostemma on transient hyperuricemia in male experimental mice.Methods Sixty male mice were randomized into six groups:A,B,C,D,E,and F,which were respectively fed with physiological saline,allopurinol,nothing,high-dose gynostemma,middle-dose gynostemma,low-dose gynostemma for continuous ten days.Once accomplished,the mice apart from group A's were intraperitoneally injected with 0.63g/kg xanthine,resulting in increasing composition of serum uric acid.Then the values of s... |
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| Keywords: | Gynostemma Transient Hyperuricemia Serum Uric Acid |
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