| 非清髓异基因造血干细胞移植治疗阵发性睡眠性血红蛋白尿2例并文献复习 |
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| 引用本文： | 张艳,仇红霞,徐卫,张苏江,李建勇,盛瑞兰,范磊,许戟,吕鑫.非清髓异基因造血干细胞移植治疗阵发性睡眠性血红蛋白尿2例并文献复习[J].临床血液学杂志,2010(2). |
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| 作者姓名： | 张艳 仇红霞 徐卫 张苏江 李建勇 盛瑞兰 范磊 许戟 吕鑫 |
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| 作者单位： | 南京医科大学第一附属医院江苏省人民医院血液科; |
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| 摘 要： | 目的:探讨非清髓异基因造血干细胞移植(NST)治疗阵发性睡眠性血红蛋白尿(PNH)的疗效。方法:采用HLA全相合的同胞外周血造血干细胞移植,经环磷酰胺(CTX)、福达拉滨(Flud)和抗人淋巴细胞免疫球蛋白(ALG)方案进行NST预处理,环孢素A(CsA)、甲氨喋呤(MTX)和霉酚酸酯(MMF)三联预防移植物抗宿主病(GVHD)。结果:病例1在确诊后就进行了NST,输注CD34+细胞3.51×106/kg(按受者体重计算),第28天成功植入,无严重的GVHD表现及并发症;病例2在PNH确诊17年后进行NST,输注CD34+细胞数量2.2×106/kg,第60天成功植入,分别出现急性和慢性GVHD。结论:同胞全相合的NST是治疗PNH的有效方法,在PNH诊断早期进行NST以及回输足量的CD34+细胞是NST的有益因素。
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| 关 键 词： | 造血干细胞移植 血红蛋白尿 阵发性 |
Successful application of nonmyeloablative stem cell transplantation in two paroxysmal nocturnal hemoglobinuria patients and literature review |
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| ZHANG Yan QIU Hongxia XU Wei ZHANG Sujiang LI Jianyong SHENG Ruilan FAN Lei XU Ji LU Xin.Successful application of nonmyeloablative stem cell transplantation in two paroxysmal nocturnal hemoglobinuria patients and literature review[J].Journal of Clinical Hematology,2010(2). |
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| Authors: | ZHANG Yan QIU Hongxia XU Wei ZHANG Sujiang LI Jianyong SHENG Ruilan FAN Lei XU Ji LU Xin |
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| Institution: | Department of Hematology/a>;First Affiliated Hospital of Nanjing Medical University/a>;Jiangsu Province Hospital/a>;Nanjing/a>;210029/a>;China |
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| Abstract: | Objective:This study was aimed to evaluate the effect of nonmyeloablative stem cell transplantation (NST) in paroxysmal nocturnal hemoglobinuria (PNH).Method:NST was performed with conditioning regimen consisting of cyclophosphamide,anti-lymphocyte globulin and fludarabine. The patients received peripheral blood stem cells from their human leukocyte antigen-matched siblings. Prophylaxis against graft-vs-host disease was performed with cyclosporine A,mycophenolate mofetil and methotrexate.Result:The results ... |
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| Keywords: | nonmyeloablative stem cell transplantation hemoglobinuria paroxysmal |
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