乙型肝炎患者血清纤维化指标与血脂水平检测的临床意义

目的：探讨乙型肝炎患者血清纤维化指标与血脂水平联合检测的诊断价值.方法：随机选择在我院治疗的乙型肝炎患者108例作为实验组,抽取健康体检者36例为对照组,同时检测所有对象肝纤维化4项和血脂6项水平,并对结果进行统计分析.结果：实验组各组患者肝纤维化的检测指标平均值均高于对照组.其中重型肝炎组和肝炎肝硬化组的HA、LN、PCⅢ、ⅣC的值比急性肝炎组患者明显升高,差异有统计学意义（P＜0.05）;TG在急性肝炎组与对照组比较明显升高,差异有统计学意义（P＜0.01）;除肝炎肝硬化组外,在其他肝病组TC低于对照组,差异有统计学意义（P＜0.01）;LDL-C在肝炎肝硬化组明显下降,差异有统计学意义（P＜0.01）;HDL-C、APOA1在各组的下降差异均有统计学意义（P＜0.01）;APOB仅在肝炎肝硬化组下降差异有统计学意义（P＜0.01）.结论：通过综合指标血清肝纤维化及血脂的联合检测,能准确反映乙型肝炎患者的严重程度,对临床诊断和治疗有指导意义.

Clinical significance of the serum fibrosis index of hepatitis B patients and the blood lipid level detection

Objective. To investigate the diagnosis values of the combined detection of serum fibrosis indexes and blood lipids level detection in patients with hepatitis B. Methods： 108 patients with hepat while itis B received treatment in our hospital were randomlyselected as the experimental group, 36 cases of the healthy check-up as the control group. The fibrosis markers of PCIII, PCIV, HA and LN, and the lipids levels of CHOL, TG, HDL-C, LDL-C, APOA1 and APOB of all the subjects were detected and their results were statistically analyzed. Results： The average results of all the indexes in the experimental groups were higher than those of the control group. HA, LN, PCⅢ and ⅣC values in the fulminant hepatitis group and the cirrhosis group increase more obvious ly than those in the group with acute hepatitis, which was of statistical difference （P〈0.05） ; TG in the acute hepatitis group increased significantly compared with that in the control group, which was of Significant difference （P〈0.01） ; TC, except in the hepatitis cirrhosis group, in the other liver disease groups were lower than that of the control group, which was of statistical difference （P 〈0.01） ; LDL-C decreased more obviously in the hepatitis cirrhosis group, which was of statistical difference （P〈0.01） ; HDL-C and APOA1 decreased in each group, which was of statistical difference （P〈0. 01）; and APOB decreased only in the hepatitis cirrhosis group, which was of significant difference （P〈0. 01）. Conclusion： Through the comprehensive indexes of the serum liver fibrosis and the combined detection of blood lipid in patients with hepatitis B liver disease, it can accurately reflect the severity of the hepatitis B liver disease,and it is of guidance significance in clinical diagnesis and treatment.