血胱抑素C对新生儿窒息后肾损害的诊断

目的探讨血胱抑素C（CysC）对窒息新生儿肾功能损害的早期诊断价值。方法将入选新生儿分为两组：对照组20例、窒息组30例。窒息组又分为轻度窒息组20例、重度窒息组10例。测定患儿24h内血CysC、血肌酐（SCr）、血尿素氮（BUN）,各组进行统计学分析。结果窒息组血CysC明显高于对照组,两组间差异有统计学意义（P〈0.01）。血BUN和Cr窒息组与对照组间差异无统计学意义（P〉0.05）。重度窒息组血CysC明显高于轻度窒息组,差异有统计学意义（P〈0.01）。结论血CysC可作为窒息新生儿肾功能的早期诊断指标,且敏感性优于SCr和BUN。

Value of Serum Cystatin C in Diagnosis of Kidney Injury Induced by Neonatal Asphyxia

Objective To study the value of serum cystatin C（Cys-C） in early diagnosis of kidney injury induced by neonatal asphyxia.Methods 50 newborns were divided into control group（20 cases）and asphyxiated group（30 cases）which were subsequently divided into mildly asphyxiated group（20 cases） and severely asphyxiated group（10 cases）.The serum levels of Cys-C,creatinine（SCr） and urea（BUN） were checked and compared in the first 24 hours.Results Compared with control group,the level of Cys-C was apparently higher in asphyxiated group.And compared with mildly asphyxiated group,the level of Cys-C was apparently higher in severely asphyxiated group too,there was a statistic difference（P0.01）.While there was no statistic difference（P0.05） between control group and asphyxiated group in the level of BUN and SCr.Conclusion Serum Cys-C can be used as a early diagnostic criterion of kidney injury induced by neonatal asphyxia with higher sensitivity as compared to SCr and BUN.