卡介菌多糖核酸注射液对2型糖尿病患者免疫功能的调节

目的:观察卡介菌多糖核酸注射液对2型糖尿病患者免疫功能的影响。方法:64例2型糖尿病患者随机分为治疗组与对照组。对照组单纯控制血糖;治疗组控制血糖同时隔日皮下注射卡介菌多糖核酸1mL,共36d。观察2组治疗前1个月与治疗后1个月血IgA、IgG、IgM、T淋巴细胞亚群、糖化血红蛋白(HbA1c)、人均感染事件的变化。结果:2组IgG、IgM、CD4、CD4/CD8比值均较治疗前升高,但治疗组更明显(P<0.05);2组人均感染事件较治疗前均降低,但治疗组更明显(P<0.05);2组HbA1c均较治疗前下降,但治疗组更明显(P<0.05)。结论:卡介菌多糖核酸可改善2型糖尿病患者的免疫功能,有利于血糖控制。

Polysaceharidc Nuclcic Acid Fraction of Bacillus Calmette Guerin(BCG-PNA)Injection in the Regulation of Immune Function in Type 2 Diabetic Patients

OBJECTIVE:To observe the effect of polysaceharidc nuclcic acid fraction of Bacillus Calmette Guerin(BCG-PNA)injection on the immune function in type-2 diabetic patients.METHODS:A total of 64 patients with type-2 diabetes were randomly divided into treated group and control group:the control group given blood glucose control alone while the treatment group was injected hypodermically with 1mL BCG-PNA injection every other day for 36 days plus the blood glucose control.Levels of IgA,IgG,IgM,T-lymphocytesubsets,HbA1c and the per capita infection event of two groups were monitored before treatment and after 1 month's treatment.RESULTS:As compared with before treatment,IgG,IgM,CD4(%),and CD4/CD8 ratio were increased in both groups,much as in the treatment group(P<0.05);the per capita infection events were reduced in both groups,much as in the treatment group(P<0.05),and HbA1c were decreased in both groups,much as in the treatment group(P<0.05).CONCLUSION:BCG-PNA can improve the immune function in type-2 diabetic patients,which is conducive to the blood glucose control.