扩张型心肌病与HLA-B*基因的多态性关系

目的探讨北方汉族人扩张型心肌病(dilated cardiomyopathy,DCM)遗传易感性与人类主要组织相容性复合体(HLA-B*)基因多态性的关系。方法采用聚合酶链反应和顺序特异性引物(PCR-SSP)基因多态性分析方法,对31例扩张型心肌病患者及29例无血缘关系健康人的HLA-B*各等位基因及亚基因进行检测分析。结果HLA-B*35基因与DCM呈正相关(相对危险度RR=3．9375,P<0．05),其他HLA-B*各等位基因未见异常,差异均无统计学意义(P>0．05)。结论HLA-B*35基因可能是北方地区汉族人DCM的致病易感基因之一,为揭示DCM的发病机制中免疫遗传学所起的作用提供了重要信息和依据。

HLA-B* gene polymorphism in patients with dilated cardiomyopathy

Objective In order to study the correlation between HLA-B* gene polymorphism and dilated cardiomyopathy (DCM). Methods HLA-B* gene polymorphism in 31 patients with DCM and 29 normal control subjects was analyzed using polymerase chain reaction-sequence specific primer(PCR-SSP) technique. Results The frequency of HLA-B*35 allele was significantly higher in patients than that in the controls with a relative risk (RR) in DCM patients of 3.9375 (P < 0.05). Conclusions These findings further verify that immunogenetics plays a predominant pathogenetic role in a subset of DCM patients. Individuals carrying HLA-B*35 alleles may be susceptible to DCM.