中药白芨胶作为血管栓塞剂的实验研究

目的研究中药白芨胶作为血管栓塞剂的有效性、安全性及相关特性。材料与方法从中药白芨茎块中提取有效成分，制备成白芨胶栓塞剂。对其进行一系列有关特性的鉴定，并应用白芨胶进行４头健康猪的肝动脉栓塞实验。结果（１）白芨胶为一种均质的胶状物，有一定粘滞性，相对粘度２３２４．６ｍｍ２／ｓ，不透Ｘ线，易经４Ｆ导管注射；（２）白芨胶具有良好的血液相容性和组织相容性，无致热原性及毒性作用；（３）白芨胶－丝裂霉素Ｃ（ＭＭＣ）体外混合后，无分层及悬浮现象，释放ＭＭＣ５０％约需１．８小时，１００％需３．４小时；（４）白芨胶主要栓塞末梢小动脉，栓塞牢靠，维持时间可达５周，不易形成侧支循环；（５）白芨胶栓塞对正常肝组织损伤轻微，未出现肝细胞坏死。结论白芨胶具有良好的血管栓塞作用、载体特性和缓释特性，使用方便、安全，是一种较理想的末梢型血管栓塞剂。

Bletilla colloid as a vascular embolization agent: experimental studies

Purpose To study the efficacy, safety and related characteristics of bletilla colloid as a vascular embolization agent. Materials and methods We prepared bletilla colloid as a vascular embolization agent from the stem tubers of bletilla striata of Chinese medicinal herb. Related characteristics of bletilla colloid were studied. In four pigs hepatic arterial embolization was performed with the bletilla colloid. Results The bletilla colloid was a homogenous viscous colloid whose relative viscosity was 2324.6 mm 2/s. It was easily injected through 4 F catheter and hyperattenuating under fluoroscopy, meanwhile, with good histocompatibility and hemo compatibility, without pyrogenetic response and toxicity. In vitro, the mixture of bletilla colloid and MMC did not produce separation and suspention phenomena but released 50% of MMC at 1.8h and 100% at 3.4h. The bletilla colloid mainly embolized peripheral arteries, maintaining occlusion for 5 weeks and without formation of collateral circulation. The injuries of normal hepatic tissues were slight, without hepatic cytonecrosis. Conclusions Bletilla colloid, safe and effective in use with angioembolic function and characteristics of carrier and slow release, is a potential peripheral embolization agent.