基于轻质碳酸钙的齐墩果酸固体分散体的研究

采用溶剂法制备齐墩果酸-轻质碳酸钙固体分散体,运用差示扫描量热法、扫描电镜等方法对其微观结构、物理特征等进行分析,并对其体外溶出行为和稳定性进行考察,研究轻质碳酸钙作为齐墩果酸固体分散体载体的特性。差示扫描量热分析结果显示,齐墩果酸以无定形形式分散于载体中,体外溶出结果表明,齐墩果酸-轻质碳酸钙(1:5)固体分散体在45 min时药物的累积溶出达90%以上;6个月稳定性加速试验结果显示,该固体分散体的药物溶出和含量未发生明显变化。将轻质碳酸钙作为齐墩果酸固体分散体的载体,能显著改善齐墩果酸的溶出,且其稳定性较好,对实际生产有一定的应用价值。

Study on solid dispersion of precipitated calcium carbonate-based oleanolic acid

Oleanolic acid-precipitated calcium carbonate solid dispersion was prepared by using solvent evaporation method. The microscopic structure and physicochemical properties of solid dispersion were analyzed using differential scanning calorimetry and scanning electron microscopy (SEM). And its in vitro release also was investigated. The properties of the precipitated calcium carbonate was studied which was as a carrier of oleanolic acid solid dispersion. Differential scanning calorimetry analysis suggested that oleanolic acid may be present in solid dispersion as amorphous substance. The in vitro release determination results of oleanolic acid-precipitated calcium carbonate (1:5) solid dispersion showed accumulated dissolution rate of oleanolic acid was up to 90% at 45 min. Accelerating experiment showed that content and in vitro dissolution of oleanolic acid solid dispersion did not change after storing over 6 months. The results indicated that in vitro dissolution of oleanolic acid was improved greatly by the solid dispersion with precipitated calcium carbonate as a carrier. The solid dispersion is a stabilizing system which has actual applied value.