16例原发性胃癌的细胞遗传学研究

用改良的直接法分析了１６例原发性胃癌的细胞遗传学改变，其染色体变化可分为简单型和复杂型两种。简单型只涉及１～３条染色体改变，以染色体三体为主，其中８号和９号染色体三体可能构成胃癌的一个细胞遗传学亚型。复杂型涉及较多的染色体数目和结构异常，经常出现的结构异常为７ｑ－、３ｐ－和１ｐ－，其中７ｑ－为本研究中最一致的结构异常，可能是原发性胃癌的特征性染色体改变之一。

CYTOGENETIC STUDIES OF SIXTEEN PRIMARY GASTRIC CANCERS

An improved method of direct chromosome preparations was adopted in the cytogenetic study of 16 primary gastric carcinomas.Chromosome rearrangements in this kind of cancer may be divided into the simple and the complicated types.The simple type involves 1 to 3 chromosomal changes,the most commonly observed abnormalities are trisomies. The complicated one,on the other hand,includes much more chromosome numerical and structural aberrations. It is suggested that trisomies 8 and 9 may represent a cytogenetic subgroup of gastric cancer. The structural abnormalities which occurred most frequently in gastric cancer are 7q-,3p-and 1p-. The 7q-was the most consistent change(13/16)in the present study and might be regarded as the characteristic chromosome rearrangement in gastric cancer.