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Mapping postnatal mouse brain development with diffusion tensor microimaging |
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| Authors: | Zhang Jiangyang Miller Michael I Plachez Celine Richards Linda J Yarowsky Paul van Zijl Peter Mori Susumu |
| Institution: | a Johns Hopkins University, School of Medicine, Department of Radiology, Division of NMR Research, 720 Rutland Avenue, Baltimore, MD 21205, USA;b Department of Biomedical Engineering, 720 Rutland Avenue, Baltimore, MD 21205, USA;c Johns Hopkins University, Center of Imaging Science, 3400 North Charles Street, Baltimore, MD 21218, USA;d University of Maryland School of Medicine, Department of Anatomy and Neurobiology and The Program in Neuroscience, 685 West Baltimore Street, Baltimore, MD 21201, USA;e Department of Pharmacology and Experimental Therapeutics, 685 West Baltimore Street, Baltimore, MD 21201, USA;f F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA |
| Abstract: | While mouse brain development has been extensively studied using histology, quantitative characterization of morphological changes is still a challenging task. This paper presents how developing brain structures can be quantitatively characterized with magnetic resonance diffusion tensor microimaging coupled with techniques of computational anatomy. High resolution diffusion tensor images of ex vivo postnatal mouse brains provide excellent contrasts to reveal the evolutions of mouse forebrain structures. Using anatomical landmarks defined on diffusion tensor images, tissue level growth patterns of mouse brains were quantified. The results demonstrate the use of these techniques to three-dimensionally and quantitatively characterize brain growth. |
| Keywords: | Mouse brain development Diffusion tensor Microimaging Computational neuroanatomy |
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