拟诊Weary-Kindler综合征一例

患者男，51岁，全身红斑、角化、皮肤异色、肢端水疱7年余，并伴有皮肤萎缩、光敏感、并指、粘膜损害、甲破坏、眼睑内翻、掌趾角化、假阿洪病、龋齿。皮肤病理：表皮角化过度，表皮萎缩，基底细胞液化变性，可见胶样小体。可见一处皮下裂隙，真皮浅层可见大量游离色素和嗜色素细胞。拟诊：Weary-kindler综合征。

Suspected Weary-Kindler syndrome: a case report

A 51-year old male patient, who was suffered from extensive erythema, keratoderma, poikiloderma and acral blister formation for seven years, together with skin atrophy, photosensitivity, syndactyly, mucosal involvement, nail dystrophy, entropion of the eye lids, palmoplantar keratoderma, pseudoainhum and dental caries. Histopathology examination showed mild hyperkeratosis and atrophy of the epidermis, liquefaction degeneration of basal cell and colloid bodies. There was a subepidermal cleft, many melanophages and free pigments were observed in upper dermis. Suspected diagnosis: Weary-kindler syndrome.