药学监护参与抗菌药物合理应用的对照研究

目的探讨抗菌药物合理应用的有效途径。方法对医院各临床科室2004年（药学监护参与用药前）和2005年（药学监护参与用药后）住院病历抗菌药物不合理应用情况进行对照研究。结果存在抗菌药物不合理应用的病历数由药学监护前的22．8％下降到药学监护后的7．2％（P〈0．01），存在抗菌药物不合理应用总项目750项，其中药学监护前578项（占77.1％），药学监护后172项（占22.9％）。药学监护前临床应用抗菌药物存在的主要问题，如抗菌药物选择不当、给药不当和用药疗程不当等，在药学监护后均有显著改善。结论药学监护促进了抗菌药物合理应用，为医院抗菌药物的合理应用提供了一种有效可行的模式。

A Comparison Study for Pharmaceutical Care Participate in Rational Use of Antibiotics

Objective To explore the effective ways of the rational use of antibiotics.Methods The in-patient medical records of all clinical departments in the hospital were selected.To study the difference between 2004(before pharmaceutical care)and 2005(after pharmaceutical care)about the irrational use of antibiotics.Results The medical records showed the irrational use of antibiotics reduced from 22.8%(before pharmaceutical care)to 7.2%(after pharmaceutical care)(P < 0.01).750 items of the irrational use of antibiotics,of 578 items before pharmaceutical care,accounted for 77.1%in total;of 172 items after pharmaceutical care,accounted for 22.9%.Some major problems such as the irrational choice of antibiotics,the irrational use of antibiotics and the irrational treatment course of antibiotics were improved significantly after pharmaceutical care.Conclusion Pharmaceutical care is the effective way to promote the rational use of antibiotics.It is a practicable and effective way for rational drug use.